Advances in genetics and transgenic approaches have a continuous impact on our
understanding of Alzheimer's disease (AD) and related disorders, especially as aspects of
the histopathology and neurodegeneration can be reproduced in animal models. AD is
characterized by extracellular Aβ peptide-containing plaques and neurofibrillary aggregates
of hyperphosphorylated isoforms of microtubule-associated protein tau. A causal link
between Aβ production, neurodegeneration and dementia has been established with the …