A century of Alzheimer's disease

M Goedert, MG Spillantini - science, 2006 - science.org
science, 2006science.org
One hundred years ago a small group of psychiatrists described the abnormal protein
deposits in the brain that define the most common neurodegenerative diseases. Over the
past 25 years, it has become clear that the proteins forming the deposits are central to the
disease process. Amyloid-β and tau make up the plaques and tangles of Alzheimer's
disease, where these normally soluble proteins assemble into amyloid-like filaments. Tau
inclusions are also found in a number of related disorders. Genetic studies have shown that …
One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-β and tau make up the plaques and tangles of Alzheimer's disease, where these normally soluble proteins assemble into amyloid-like filaments. Tau inclusions are also found in a number of related disorders. Genetic studies have shown that dysfunction of amyloid-β or tau is sufficient to cause dementia. The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis.
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