[HTML][HTML] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation
B Lamothe, A Besse, AD Campos, WK Webster… - Journal of Biological …, 2007 - ASBMB
Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key mediator in
proximal signaling of the interleukin-1/Toll-like receptor and the TNF receptor superfamily.
Analysis of TRAF6-deficient mice revealed a fundamental role of TRAF6 in
osteoclastogenesis; however, the molecular mechanism underlying TRAF6 signaling in this
biological process is not understood. Recent biochemical evidence has indicated that
TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-κB …
proximal signaling of the interleukin-1/Toll-like receptor and the TNF receptor superfamily.
Analysis of TRAF6-deficient mice revealed a fundamental role of TRAF6 in
osteoclastogenesis; however, the molecular mechanism underlying TRAF6 signaling in this
biological process is not understood. Recent biochemical evidence has indicated that
TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-κB …