[HTML][HTML] The NF-κB signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death
I Rivera-Walsh, ME Cvijic, G Xiao, SC Sun - Journal of Biological Chemistry, 2000 - ASBMB
Stimulation of T cells by antigens or mitogens triggers multiple signaling pathways leading to
activation of genes encoding interleukin-2 and other growth-regulatory cytokines. The same
stimuli also activate the gene encoding an apoptosis-inducing molecule, Fas ligand (FasL),
which contributes to activation-induced cell death. It has been proposed that the signaling
pathways involved in cytokine gene induction also contribute to activation-induced FasL
expression; however, genetic evidence for this proposal is lacking. In the present study, the …
activation of genes encoding interleukin-2 and other growth-regulatory cytokines. The same
stimuli also activate the gene encoding an apoptosis-inducing molecule, Fas ligand (FasL),
which contributes to activation-induced cell death. It has been proposed that the signaling
pathways involved in cytokine gene induction also contribute to activation-induced FasL
expression; however, genetic evidence for this proposal is lacking. In the present study, the …