CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocyte subsets
U Thienel, J Loike, MJ Yellin - Cellular immunology, 1999 - Elsevier
CD154–CD40 interactions play key roles in humoral and cellular immune responses. With
regard to the latter, ligation of CD40 on endothelial cells upregulates important intercellular
adhesion molecules. Activated endothelial cells also regulate leukocyte trafficking into
inflammatory sites by secreting chemokines. In this study we asked whether CD154
mediated signals induce human umbilical vein endothelial cells (HUVEC) to secrete
neutrophil or peripheral blood mononuclear cell (PBMC) chemoattractants. HUVEC were …
regard to the latter, ligation of CD40 on endothelial cells upregulates important intercellular
adhesion molecules. Activated endothelial cells also regulate leukocyte trafficking into
inflammatory sites by secreting chemokines. In this study we asked whether CD154
mediated signals induce human umbilical vein endothelial cells (HUVEC) to secrete
neutrophil or peripheral blood mononuclear cell (PBMC) chemoattractants. HUVEC were …