[HTML][HTML] Tissue factor around dermal vessels has bound factor VII in the absence of injury

M Hoffman, CM Colina, AG McDonald… - Journal of Thrombosis …, 2007 - Elsevier
Background:'Idling'or ongoing low‐level activity of the tissue factor (TF) pathway is a
postulated mechanism by which the coagulation process can become active without a lag
period at sites of injury. Objective: To determine whether TF around cutaneous vessels has
bound factor VIIa in the absence of injury, and thus could participate in the idling process.
Methods: Immunostaining of mouse skin with antibodies against a 15‐residue peptide from
the sequence of mouse TF, and against the whole extracellular portion of TF. Results: The …