[HTML][HTML] Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites
C Lecut, V Arocas, H Ulrichts, A Elbaz… - Journal of Biological …, 2004 - ASBMB
Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is
known about its interaction with its ligands. In binding assays using soluble or cell-
expressed human GPVI, we observed that (i) collagen, and the GPVI-specific ligands
collagen-related peptides (CRP) and convulxin, competed with one another for the binding
to GPVI and (ii) monoclonal antibodies directed against the extracellular part of the human
receptor displayed selective inhibitory properties on GPVI interaction with its ligands …
known about its interaction with its ligands. In binding assays using soluble or cell-
expressed human GPVI, we observed that (i) collagen, and the GPVI-specific ligands
collagen-related peptides (CRP) and convulxin, competed with one another for the binding
to GPVI and (ii) monoclonal antibodies directed against the extracellular part of the human
receptor displayed selective inhibitory properties on GPVI interaction with its ligands …