[HTML][HTML] Molecular Cloning and Expression of the Pituitary Glycoprotein HormoneN-Acetylgalactosamine-4-O-sulfotransferase

G Xia, MR Evers, HG Kang, M Schachner… - Journal of Biological …, 2000 - ASBMB
N-Linked oligosaccharides terminating with the sequence SO 4-4-GalNAcβ1, 4GlcNAcβ1,
2Manα are present on the pituitary hormones lutropin (LH), thyrotropin, and pro-
opiomelanocortin. The sulfated structures on LH are essential for expression of its biologic
function in vivo. We have cloned the N-acetylgalactosamine-4-sulfotransferase (GalNAc-4-
ST1, GenBank TM accession number AF300612), which mediates sulfate addition to the N-
linked oligosaccharides on LH and other pituitary glycoproteins with terminal (β1, 4-linked …