Exaggerated responses to chlorine inhalation among persons with nonspecific airway hyperreactivity

A D'Alessandro, W Kuschner, H Wong, HA Boushey… - Chest, 1996 - Elsevier
Although chlorine gas is a common irritant exposure, little is known about airway responses
to chlorine inhalation among persons with baseline airway hyperreactivity. We wished to
determine whether such persons manifest an exaggerated response to chlorine compared
with normal subjects. We studied 10 subjects, five with and five without airway
hyperresponsiveness (HR) after exposure to 1.0 ppm chlorine and five persons, all with HR,
to 0.4 ppm chlorine. After 1.0 ppm inhalation, there was a significant (p< 0.05) fall …