Chlorine inhalation produces nasal airflow limitation in allergic rhinitic subjects without evidence of neuropeptide release

D Shusterman, J Balmes, MA Murphy, CF Tai… - Neuropeptides, 2004 - Elsevier
BACKGROUND: Seasonal allergic rhinitic (SAR) subjects are more physiologically reactive
to airborne irritants than non-rhinitic (NR) subjects; however the mechanism underlying this
difference is unclear. OBJECTIVE: We sought to determine whether irritant-induced nasal
airflow limitation involves neuropeptide release into nasal lining fluid, and if so, whether
such release occurs differentially by rhinitic status. METHODS: Eight SAR and 8 NR subjects
were exposed to 1.0 ppm chlorine and filtered air in random order during separate visits; …