Schistosomes: the road from host–parasite interactions to vaccines in clinical trials
A Capron, G Riveau, M Capron, F Trottein - Trends in parasitology, 2005 - cell.com
A Capron, G Riveau, M Capron, F Trottein
Trends in parasitology, 2005•cell.comInsights over recent years into the interactions between helminths, including schistosomes,
and the immune system have generated new concepts in immunology and significant
advances in vaccine strategies. Here, we report recent advances that substantially increase
our understanding of the nature of the host innate and adaptive responses to schistosomes
and on strategies elaborated by the parasite to manipulate such responses. We also
describe the long road that has allowed us to move from the identification of an anti …
and the immune system have generated new concepts in immunology and significant
advances in vaccine strategies. Here, we report recent advances that substantially increase
our understanding of the nature of the host innate and adaptive responses to schistosomes
and on strategies elaborated by the parasite to manipulate such responses. We also
describe the long road that has allowed us to move from the identification of an anti …
Insights over recent years into the interactions between helminths, including schistosomes, and the immune system have generated new concepts in immunology and significant advances in vaccine strategies. Here, we report recent advances that substantially increase our understanding of the nature of the host innate and adaptive responses to schistosomes and on strategies elaborated by the parasite to manipulate such responses. We also describe the long road that has allowed us to move from the identification of an anti-schistosome vaccine candidate, a 28kDa glutathione-S-transferase, to its recent evaluation in human clinical trials.
cell.com