Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China

SH Xiao, W Hui-Ming, M Tanner, J Utzinger, W Chong - Acta tropica, 2005 - Elsevier
We review, for the first time, a 20-year Chinese story of research and development
pertaining to tribendimidine, a promising anthelmintic agent that is safe and exhibits a broad
spectrum of activity. Tribendimidine was first synthesized at the National Institute of Parasitic
Diseases in Shanghai in the mid 1980s. In laboratory studies, tribendimidine showed high
efficacy against Nippostrongylus braziliensis in rats, Necator americanus in hamsters,
Ancylostoma caninum and Toxocara canis in dogs, and Syphacia mesocriceti in mice …