RNA interference (RNAi) has been used extensively in model organisms such as
Caenorhabditis elegans. Methods developed for RNAi in C. elegans have also been used in
parasitic nematodes. However, RNAi in parasitic nematodes has been unsuccessful or has
had limited success. Studies of genes essential for RNAi in C. elegans and of RNAi in
Caenorhabditis spp. other than C. elegans suggest two complementary, and testable,
hypotheses for the limited success of RNAi in animal parasitic nematodes. These are:(i) that …