On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion
J Cassuto, M Jodal, R Tuttle… - Scandinavian journal of …, 1981 - Taylor & Francis
J Cassuto, M Jodal, R Tuttle, O Lundgren
Scandinavian journal of gastroenterology, 1981•Taylor & FrancisIntestinal secretion was produced in anesthetized cats and rats by exposing isolated
intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-
conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in
the intestinal segments markedly inhibited the rate of choleraic secretion, and in most
experiments a net absorption of fluid was observed. The results suggest that intramural
nervous mechanisms are involved in the pathogenesis of choleraic secretion.
intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-
conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in
the intestinal segments markedly inhibited the rate of choleraic secretion, and in most
experiments a net absorption of fluid was observed. The results suggest that intramural
nervous mechanisms are involved in the pathogenesis of choleraic secretion.
Intestinal secretion was produced in anesthetized cats and rats by exposing isolated intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in the intestinal segments markedly inhibited the rate of choleraic secretion, and in most experiments a net absorption of fluid was observed. The results suggest that intramural nervous mechanisms are involved in the pathogenesis of choleraic secretion.
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