B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H. pylori seronegative …
GA Losonsky, KL Kotloff, RI Walker - Vaccine, 2003 - Elsevier
GA Losonsky, KL Kotloff, RI Walker
Vaccine, 2003•ElsevierTo investigate whether B cell-specific responses could be elicited in the gastric mucosa of
Helicobacter pylori (HP) naive subjects, five volunteers ingested three doses of a HP killed
whole cell (HWC) vaccine with 25μg of recombinant heat-labile toxin (LTR192G). Two of
three subjects had detectable LTR192G and HWC IgA antibody secreting cell (ASC) gastric
responses. LTR192G and HWC responses in duodenal were 5–14-fold higher than those
detected in antral biopsies (P< 0.01 and P= 0.05, respectively). These results provide the …
Helicobacter pylori (HP) naive subjects, five volunteers ingested three doses of a HP killed
whole cell (HWC) vaccine with 25μg of recombinant heat-labile toxin (LTR192G). Two of
three subjects had detectable LTR192G and HWC IgA antibody secreting cell (ASC) gastric
responses. LTR192G and HWC responses in duodenal were 5–14-fold higher than those
detected in antral biopsies (P< 0.01 and P= 0.05, respectively). These results provide the …
To investigate whether B cell-specific responses could be elicited in the gastric mucosa of Helicobacter pylori (HP) naive subjects, five volunteers ingested three doses of a HP killed whole cell (HWC) vaccine with 25μg of recombinant heat-labile toxin (LTR192G). Two of three subjects had detectable LTR192G and HWC IgA antibody secreting cell (ASC) gastric responses. LTR192G and HWC responses in duodenal were 5–14-fold higher than those detected in antral biopsies (P<0.01 and P=0.05, respectively). These results provide the first evidence that specific gastric B cell responses can be induced in HP-non-infected individuals following oral immunization.
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