Can oral cholera vaccination play a role in controlling a cholera outbreak?
P Calain, JP Chaine, E Johnson, ML Hawley… - Vaccine, 2004 - Elsevier
P Calain, JP Chaine, E Johnson, ML Hawley, MJ O'Leary, H Oshitani, CL Chaignat
Vaccine, 2004•ElsevierControl measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia),
included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD
103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to
evaluate the practicality of use and effectiveness of this vaccine. Under field conditions
encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2%(95% CI: 71.9–
84.6%) in the target population. Retrospective analysis suggests that mass vaccination with …
included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD
103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to
evaluate the practicality of use and effectiveness of this vaccine. Under field conditions
encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2%(95% CI: 71.9–
84.6%) in the target population. Retrospective analysis suggests that mass vaccination with …
Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% CI: 71.9–84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures.
Elsevier