Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes
JP Vanderberg, U Frevert - International journal for parasitology, 2004 - Elsevier
Previous studies have shown that mosquitoes inject Plasmodium sporozoites into avascular
portions of the skin of their rodent host rather than directly into the blood circulation. Then,
over time, these sporozoites move into the circulation, from where they reach the liver to
initiate a malaria infection. By use of intravital microscopy of the skin, we present direct
morphological evidence of mosquito probing that introduces sporozoites into avascular
tissue, of the migration of these sporozoites through the dermis and into blood vessels, and …
portions of the skin of their rodent host rather than directly into the blood circulation. Then,
over time, these sporozoites move into the circulation, from where they reach the liver to
initiate a malaria infection. By use of intravital microscopy of the skin, we present direct
morphological evidence of mosquito probing that introduces sporozoites into avascular
tissue, of the migration of these sporozoites through the dermis and into blood vessels, and …