Antibody-mediated protection against intracellular pathogens
A Casadevall - Trends in microbiology, 1998 - cell.com
Trends in microbiology, 1998•cell.com
The view that antibody-mediated protection is unimportant against intracellular pathogens is
not supported by the literature. In fact, there is convincing evidence that antibody can protect
against many important intracellular pathogens. The challenge now is to identify antigens
that elicit protective antibodies, use them in vaccine design and understand how humoral
and cellular immune mechanisms cooperate.
not supported by the literature. In fact, there is convincing evidence that antibody can protect
against many important intracellular pathogens. The challenge now is to identify antigens
that elicit protective antibodies, use them in vaccine design and understand how humoral
and cellular immune mechanisms cooperate.
Abstract
The view that antibody-mediated protection is unimportant against intracellular pathogens is not supported by the literature. In fact, there is convincing evidence that antibody can protect against many important intracellular pathogens. The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate.
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