IL-17 cytokine family
M Kawaguchi, M Adachi, N Oda, F Kokubu… - Journal of Allergy and …, 2004 - Elsevier
A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-
receptor signaling system. Functional studies have provided evidence for its importance in
the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-
17F, have been best characterized both in vitro and in vivo, and have been shown to be
proinflammatory in nature. This proinflammatory activity is exemplified by their involvement
in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the …
receptor signaling system. Functional studies have provided evidence for its importance in
the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-
17F, have been best characterized both in vitro and in vivo, and have been shown to be
proinflammatory in nature. This proinflammatory activity is exemplified by their involvement
in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the …