Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse

L Kjeldsen, JB Cowland, N Borregaard - Biochimica et Biophysica Acta …, 2000 - Elsevier
Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa lipocalin originally purified
from human neutrophils. It exists in monomeric and homo-and heterodimeric forms, the latter
as a dimer with human neutrophil gelatinase. It is secreted from specific granules of
activated human neutrophils. Homologous proteins have been identified in mouse
(24p3/uterocalin) and rat (α2-microglobulin-related protein/neu-related lipocalin). Structural
data have confirmed a typical lipocalin fold of NGAL with an eight-stranded β-barrel, but with …