[HTML][HTML] Akt-dependent phosphorylation of p27Kip1promotes binding to 14-3-3 and cytoplasmic localization
N Fujita, S Sato, K Katayama, T Tsuruo - Journal of Biological Chemistry, 2002 - ASBMB
In many human cancers, the cyclin-dependent kinase inhibitor p27 Kip1 is expressed at low
or undetectable levels. The decreased p27 Kip1 expression allows cyclin-dependent kinase
activity to cause cells to enter into S phase and correlates with poor patient survival.
Inhibition of serine/threonine kinase Akt signaling by some pharmacological agents or by
PTEN induces G 1 arrest, in part by up-regulating p27 Kip1. However, the role of Akt-
dependent phosphorylation in p27 Kip1 regulation is not clear. Here, we show that Akt …
or undetectable levels. The decreased p27 Kip1 expression allows cyclin-dependent kinase
activity to cause cells to enter into S phase and correlates with poor patient survival.
Inhibition of serine/threonine kinase Akt signaling by some pharmacological agents or by
PTEN induces G 1 arrest, in part by up-regulating p27 Kip1. However, the role of Akt-
dependent phosphorylation in p27 Kip1 regulation is not clear. Here, we show that Akt …