Escape of human solid tumors from T–cell recognition: Molecular mechanisms and functional significance
FM Marincola, EM Jaffee, DJ Hicklin, S Ferrone - Advances in immunology, 1999 - Elsevier
Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of
research have been aimed at the identification of TAA that can serve as targets for the
immunotherapy of malignant diseases. The dramatic progress in the understanding of
molecular basis of target cell recognition by cytotoxic T lymphocytes (CTL) has provided the
background to design effective strategies to identify TAA recognized by CTL on tumor cells …
may be associated with the appearance of tumor associated antigens (TAA). Decades of
research have been aimed at the identification of TAA that can serve as targets for the
immunotherapy of malignant diseases. The dramatic progress in the understanding of
molecular basis of target cell recognition by cytotoxic T lymphocytes (CTL) has provided the
background to design effective strategies to identify TAA recognized by CTL on tumor cells …