Stimulation of P2y purinoceptors induces, via nitric oxide production, endothelium-dependent relaxation of human isolated corpus cavernosum
M Shalev, F Staerman, H Allain, B Lobel, B Saiag - The Journal of urology, 1999 - Elsevier
PURPOSE: Endothelial P2y purinoceptor stimulation is known to induce vasodilatation
mediated by NO release from endothelial cells. We examined the effect of a potent P2y
agonist, adenosine-5′-O-(2-thiodiphosphate)(ADP beta S), on human corporal cavernosal
strips and its dependence on a functional endothelial lining. MATERIALS AND METHODS:
The preparations mounted in isometric conditions were precontracted by noradrenaline (NA)
at a concentration of 0.1 micro M. Increasing concentrations of ADP beta S from 1 micro M to …
mediated by NO release from endothelial cells. We examined the effect of a potent P2y
agonist, adenosine-5′-O-(2-thiodiphosphate)(ADP beta S), on human corporal cavernosal
strips and its dependence on a functional endothelial lining. MATERIALS AND METHODS:
The preparations mounted in isometric conditions were precontracted by noradrenaline (NA)
at a concentration of 0.1 micro M. Increasing concentrations of ADP beta S from 1 micro M to …