Differential effects of carboxyfullerene on MPP+/MPTP-induced neurotoxicity
AMY Lin, CH Yang, YF Ueng, TY Luh, TY Liu… - Neurochemistry …, 2004 - Elsevier
The effects of carboxyfullerene on a well-known neurotoxin, 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenyl-pyridinium (MPP+)
were investigated. In chloral hydrate-anesthetized rats, cytosolic cytochrome c was elevated
in the infused substantia nigra 4h after an intranigral infusion of MPP+. Five days after local
application of MPP+, lipid peroxidation (LP) was elevated in the infused substantia nigra.
Furthermore, dopamine content and tyrosine hydroxylase (TH)-positive axons were reduced …
tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenyl-pyridinium (MPP+)
were investigated. In chloral hydrate-anesthetized rats, cytosolic cytochrome c was elevated
in the infused substantia nigra 4h after an intranigral infusion of MPP+. Five days after local
application of MPP+, lipid peroxidation (LP) was elevated in the infused substantia nigra.
Furthermore, dopamine content and tyrosine hydroxylase (TH)-positive axons were reduced …