Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid
P Sarchielli, L Greco, A Floridi, A Floridi… - Archives of …, 2003 - jamanetwork.com
Background Recent evidence suggests an altered glutamate homeostasis in the brain of
patients with multiple sclerosis (MS), as seen in experimental models of MS. Objective To
test whether the excitotoxic insult contributes to the pathological process in MS by
measuring glutamate and aspartate levels in the cerebrospinal fluid of MS patients and
control individuals. Participants Twenty-five patients with the relapsing-remitting form of MS
during a stable clinical phase, 30 patients with relapsing-remitting MS during relapse, and …
patients with multiple sclerosis (MS), as seen in experimental models of MS. Objective To
test whether the excitotoxic insult contributes to the pathological process in MS by
measuring glutamate and aspartate levels in the cerebrospinal fluid of MS patients and
control individuals. Participants Twenty-five patients with the relapsing-remitting form of MS
during a stable clinical phase, 30 patients with relapsing-remitting MS during relapse, and …