Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 …
Objective To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine
encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS).
Design The study was a randomized, double-blind, placebo-controlled trial. Subjects
receiving placebo were crossed over into an active arm after treatment unblinding. Setting
The trial was conducted at 4 academic institutions within North America. Patients Thirty
patients with relapsing-remitting or secondary progressive MS who were not taking any …
encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS).
Design The study was a randomized, double-blind, placebo-controlled trial. Subjects
receiving placebo were crossed over into an active arm after treatment unblinding. Setting
The trial was conducted at 4 academic institutions within North America. Patients Thirty
patients with relapsing-remitting or secondary progressive MS who were not taking any …