Pristane induces a lupus-like syndrome characterized by autoantibody production and
glomerulonephritis in nonautoimmune strains of mice. Although it has been suggested that
this syndrome results from nonspecific immune activation, there is little evidence so far that B
cells are activated nonspecifically by pristane or that this promotes autoimmunity. In this
study, we examined whether polyclonal hypergammaglobulinemia occurs in pristane-
induced lupus, and its relationship to the production of anti-DNA, nRNP/Sm, and Su …