Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated …
Glutamate toxicity is a major contributor to death of oligodendroglia in diverse CNS
disorders. The goal of these studies was to investigate the mechanisms of glutamate toxicity
and trophic factor protection of the immature pro-oligodendroblast (pro-OL). Glutamate
induced time-and dose-dependent DNA fragmentation and caspase-3 activation in pro-OLs.
IGF-I or NT-3, but not CNTF, prevented apoptosis of pro-OLs by 24 h via a PI3-kinase-
dependent pathway; however, only IGF-I protected pro-OLs from glutamate toxicity through …
disorders. The goal of these studies was to investigate the mechanisms of glutamate toxicity
and trophic factor protection of the immature pro-oligodendroblast (pro-OL). Glutamate
induced time-and dose-dependent DNA fragmentation and caspase-3 activation in pro-OLs.
IGF-I or NT-3, but not CNTF, prevented apoptosis of pro-OLs by 24 h via a PI3-kinase-
dependent pathway; however, only IGF-I protected pro-OLs from glutamate toxicity through …