Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats
GL Hinks, RJM Franklin - Molecular and Cellular Neuroscience, 2000 - Elsevier
In this study we have examined whether the slower rate of CNS remyelination that occurs
with age is associated with a change in growth factor expression patterns, an association
that would provide further support for a causal relationship between growth factors and
remyelination. Using quantitative in situ hybridization we have shown that there are
differences in IGF-I, TGF-β1, and PDGF-A mRNA expression during remyelination of
lysolecithin-induced demyelination in the spinal cord of young adult and old adult rats. IGF-I …
with age is associated with a change in growth factor expression patterns, an association
that would provide further support for a causal relationship between growth factors and
remyelination. Using quantitative in situ hybridization we have shown that there are
differences in IGF-I, TGF-β1, and PDGF-A mRNA expression during remyelination of
lysolecithin-induced demyelination in the spinal cord of young adult and old adult rats. IGF-I …