Functions of transforming growth factor-β family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes
U Valcourt, A Moustakas, D Herbage - Journal of Biological Chemistry, 2002 - ASBMB
We investigated the effects of bone morphogenetic protein (BMP)-2, a member of the
transforming growth factor-β superfamily, on the regulation of the chondrocyte phenotype,
and we identified signaling molecules involved in this regulation. BMP-2 triggers three
concomitant responses in mouse primary chondrocytes and chondrocytic MC615 cells. First,
BMP-2 stimulates expression or synthesis of type II collagen. Second, BMP-2 induces
expression of molecular markers characteristic of pre-and hypertrophic chondrocytes, such …
transforming growth factor-β superfamily, on the regulation of the chondrocyte phenotype,
and we identified signaling molecules involved in this regulation. BMP-2 triggers three
concomitant responses in mouse primary chondrocytes and chondrocytic MC615 cells. First,
BMP-2 stimulates expression or synthesis of type II collagen. Second, BMP-2 induces
expression of molecular markers characteristic of pre-and hypertrophic chondrocytes, such …
