[HTML][HTML] Discrete signaling regions in the lymphotoxin-β receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of …
WR Force, AA Glass, CA Benedict, TC Cheung… - Journal of Biological …, 2000 - ASBMB
Lymphotoxin-β receptor (LTβR), a member of the tumor necrosis factor receptor superfamily,
is essential for the development and organization of secondary lymphoid tissue. Wild type
and mutant LTβR containing successive truncations of the cytoplasmic domain were
investigated by retrovirus-mediated gene transfer into HT29. 14s and in 293T cells by
transfection. Wild type receptors accumulated in perinuclear compartments and enhanced
responsiveness to ligand-induced cell death and ligand-independent activation of NFκB p50 …
is essential for the development and organization of secondary lymphoid tissue. Wild type
and mutant LTβR containing successive truncations of the cytoplasmic domain were
investigated by retrovirus-mediated gene transfer into HT29. 14s and in 293T cells by
transfection. Wild type receptors accumulated in perinuclear compartments and enhanced
responsiveness to ligand-induced cell death and ligand-independent activation of NFκB p50 …