[PDF][PDF] Estrogen Modulates the Expression of Tumor Necrosis Factor o mRNA in Phorbol Ester-Stimulated Human Monocytic
G Shanker, M Sorci-Thomas… - Lymphokine and cytokine …, 1994 - researchgate.net
Monokines, including tumor necrosis factor o (TNF-o), have been implicated in the
pathogenesis of several pathologic processes, including atherosclerosis. Because estrogen
has been found to offer a certain degree of protection against atherosclerotic progression,
we examined the effect of estrogen on the expression of TNF-ot mRNA in a monocyte-
macrophage cell line, THP-1. Cells were exposed to 12-O-tetradecanoylphorbol 13-acetate
(TPA, 50 ng/ml) for 48 or 96 h to induce differentiation. Some of the cells were treated with …
pathogenesis of several pathologic processes, including atherosclerosis. Because estrogen
has been found to offer a certain degree of protection against atherosclerotic progression,
we examined the effect of estrogen on the expression of TNF-ot mRNA in a monocyte-
macrophage cell line, THP-1. Cells were exposed to 12-O-tetradecanoylphorbol 13-acetate
(TPA, 50 ng/ml) for 48 or 96 h to induce differentiation. Some of the cells were treated with …
