Targeting the IgE molecule in allergic and asthmatic diseases: review of the IgE molecule and clinical efficacy

JA Poole, P Matangkasombut… - Journal of allergy and …, 2005 - jacionline.org
Diseases such as allergic asthma and rhinitis continue to increase in the United States,
affecting millions of persons. 1 It is well established that allergy contributes to the
pathogenesis of most asthma, especially in children and young adults. 2 Despite current
therapy (eg, inhaled corticosteroids, antileukotrienes, and bronchodilators), patients with
moderate-to-severe asthma continue to remain symptomatic and experience frequent
exacerbations of disease requiring oral corticosteroids, emergency department treatments …