Inhibition of allergen-specific IgE reactivity by a human Ig Fcγ-Fcε bifunctional fusion protein
BACKGROUND: Coaggregating FcεRI with FcγRII receptors holds great potential for
treatment of IgE-mediated disease by inhibiting FcεRI signaling. We have previously shown
that an Fcγ-Fcε fusion protein, human IgG-IgE Fc fusion protein (GE2), could inhibit FcεRI-
mediated mediator releases in vitro and in vivo. OBJECTIVE: We sought to test whether GE2
was capable of blocking mediator release from FcεRI cells sensitized with IgE in vivo or in
vitro before exposure to GE2, a critical feature for GE2 to be clinically applicable. METHODS …
treatment of IgE-mediated disease by inhibiting FcεRI signaling. We have previously shown
that an Fcγ-Fcε fusion protein, human IgG-IgE Fc fusion protein (GE2), could inhibit FcεRI-
mediated mediator releases in vitro and in vivo. OBJECTIVE: We sought to test whether GE2
was capable of blocking mediator release from FcεRI cells sensitized with IgE in vivo or in
vitro before exposure to GE2, a critical feature for GE2 to be clinically applicable. METHODS …