Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's …
X Wang, A Sarkar, F Cicchetti, M Yu, A Zhu… - Journal of the …, 2005 - Elsevier
To investigate efficacy of cystamine induced neuroprotection, we conducted PET imaging
studies of cerebral glucose metabolism with [18F] FDG (2-deoxy-2-[18F] fluoro-d-glucose)
and striatal dopamine D2 receptor function with [11C] raclopride in R6/2 transgenic
Huntington mice. In the control mice, exponentially decreasing glucose utilization was
observed in the striatum Nstr [SUV]=(41.75±11.80) 58, str* exp (−(0.041±0.007)* t [days]);
cortex Ncort [SUV]= 24.14±3.66) 58, cort* exp (−(0.043±0.007)* t [days]); and cerebellum …
studies of cerebral glucose metabolism with [18F] FDG (2-deoxy-2-[18F] fluoro-d-glucose)
and striatal dopamine D2 receptor function with [11C] raclopride in R6/2 transgenic
Huntington mice. In the control mice, exponentially decreasing glucose utilization was
observed in the striatum Nstr [SUV]=(41.75±11.80) 58, str* exp (−(0.041±0.007)* t [days]);
cortex Ncort [SUV]= 24.14±3.66) 58, cort* exp (−(0.043±0.007)* t [days]); and cerebellum …