[HTML][HTML] Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells
N Rahimi, V Dayanir, K Lashkari - Journal of Biological Chemistry, 2000 - ASBMB
Vascular endothelial growth factor (VEGF) provokes angiogenesis in vivo and stimulates
growth and differentiation of endothelial cells in vitro. Although VEGF receptor-1 (VEGFR-1)
and VEGFR-2 are known to be high affinity receptors for VEGF, it is not clear which of the
VEGFRs are responsible for the transmission of the diverse biological responses of VEGF.
For this purpose we have constructed a chimeric receptor for VEGFR-1 (CTR) and VEGFR-2
(CKR) in which the extracellular domain of each receptor was replaced with the extracellular …
growth and differentiation of endothelial cells in vitro. Although VEGF receptor-1 (VEGFR-1)
and VEGFR-2 are known to be high affinity receptors for VEGF, it is not clear which of the
VEGFRs are responsible for the transmission of the diverse biological responses of VEGF.
For this purpose we have constructed a chimeric receptor for VEGFR-1 (CTR) and VEGFR-2
(CKR) in which the extracellular domain of each receptor was replaced with the extracellular …