The structure of amyloid fibrils by electron microscopy and X-ray diffraction
M Sunde, C Blake - Advances in protein chemistry, 1997 - Elsevier
Publisher Summary The chapter discusses the structural analysis of amyloid fibrils by
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was
developed, and such preparations of purified fibrils exhibited the classic staining and
birefringent characteristics of crude amyloid samples. The further use of high-resolution
electron microscopy, examining ultrathin sections of tissue and isolated material, confirmed
the fibrillar form as the characteristic appearance of amyloid in the electron microscope. With …
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was
developed, and such preparations of purified fibrils exhibited the classic staining and
birefringent characteristics of crude amyloid samples. The further use of high-resolution
electron microscopy, examining ultrathin sections of tissue and isolated material, confirmed
the fibrillar form as the characteristic appearance of amyloid in the electron microscope. With …