Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
can be activated by fatty acids and peroxisome proliferators. The PPARα subtype mediates
the pleiotropic effects of these activators in liver and regulates several target genes involved
in fatty acid catabolism. In primary hepatocytes cultured in vitro, the PPARα gene is
regulated at the transcriptional level by glucocorticoids. We investigated if this hormonal
regulation also occurs in the whole animal in physiological situations leading to increased …