[HTML][HTML] Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor α agonists via inhibition of CCAAT box/enhancer …
P Gervois, N Vu-Dac, R Kleemann, M Kockx… - Journal of Biological …, 2001 - ASBMB
Fibrinogen is a coagulation factor and an acute phase reactant up-regulated by
inflammatory cytokines, such as interleukin 6 (IL-6). Elevated plasma fibrinogen levels are
associated with coronary heart diseases. Fibrates are clinically used hypolipidemic drugs
that act via the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). In
addition, most fibrates also reduce plasma fibrinogen levels, but the molecular mechanism is
unknown. In this study, we demonstrate that fibrates decrease basal and IL-6-stimulated …
inflammatory cytokines, such as interleukin 6 (IL-6). Elevated plasma fibrinogen levels are
associated with coronary heart diseases. Fibrates are clinically used hypolipidemic drugs
that act via the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). In
addition, most fibrates also reduce plasma fibrinogen levels, but the molecular mechanism is
unknown. In this study, we demonstrate that fibrates decrease basal and IL-6-stimulated …