[HTML][HTML] The importance of clinical research: the role of thermogenesis in human obesity
DA Schoeller - The American journal of clinical nutrition, 2001 - Elsevier
The hypothesis that human obesity is caused by deficient thermogenesis has been
proposed by many investigators throughout the 20th century. Supporting evidence was
obtained from epidemiologic studies of dietary intake, animal models with aberrant brown
adipose tissue (BAT) function, and genetic studies of human polymorphisms of genes
involved in BAT function. Supporting evidence was also obtained from clinical studies of the
thermogenic effect of meals, but these measures capture only a short portion of the day and …
proposed by many investigators throughout the 20th century. Supporting evidence was
obtained from epidemiologic studies of dietary intake, animal models with aberrant brown
adipose tissue (BAT) function, and genetic studies of human polymorphisms of genes
involved in BAT function. Supporting evidence was also obtained from clinical studies of the
thermogenic effect of meals, but these measures capture only a short portion of the day and …