An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
LA Pennacchio, M Olivier, JA Hubacek, JC Cohen… - Science, 2001 - science.org
Science, 2001•science.org
Comparison of genomic DNA sequences from human and mouse revealed a new
apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized
APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene
showed a decrease in plasma triglyceride concentrations to one-third of those in control
mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides
as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus …
apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized
APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene
showed a decrease in plasma triglyceride concentrations to one-third of those in control
mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides
as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus …
Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAVtransgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lackingApoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across theAPOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.
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