[HTML][HTML] The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver
SL Sabol, HB Brewer, S Santamarina-Fojo - Journal of lipid research, 2005 - ASBMB
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in
macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high
density lipoprotein. The ABCG1 gene is transcriptionally activated by cholesterol loading
and activators of liver X receptors (LXRs) and retinoid X receptors (RXRs) through genomic
sequences that have not been fully characterized. Here we show that ABCG1 mRNA is
induced by LXR agonists in RAW264. 7 macrophage cells, HepG2 hepatoma cells, and …
macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high
density lipoprotein. The ABCG1 gene is transcriptionally activated by cholesterol loading
and activators of liver X receptors (LXRs) and retinoid X receptors (RXRs) through genomic
sequences that have not been fully characterized. Here we show that ABCG1 mRNA is
induced by LXR agonists in RAW264. 7 macrophage cells, HepG2 hepatoma cells, and …