PGC-1α at the crossroads of type 2 diabetes
AD Attie, CM Kendziorski - Nature genetics, 2003 - nature.com
Nature genetics, 2003•nature.com
Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now,
coordinated changes in expression of genes involved in oxidative phosphorylation have
been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator
activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated
change in gene expression.
coordinated changes in expression of genes involved in oxidative phosphorylation have
been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator
activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated
change in gene expression.
Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.
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