The biogenesis of mitochondria requires the expression of a large number of genes, most of
which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13
respiratory subunits necessitating that nuclear regulatory factors play an important role in
governing nucleo-mitochondrial interactions. Two classes of nuclear transcriptional
regulators implicated in mitochondrial biogenesis have emerged in recent years. The first
includes DNA-binding transcription factors, typified by nuclear respiratory factor (NRF)-1 …