Relationship of cholesterolgenesis to DNA synthesis and proliferation by lens epithelial cells in culture

GN El-Sayed, RJ Cenedella - Experimental eye research, 1987 - Elsevier
Cholesterolgenesis could be important for both cell growth and DNA synthesis in many cell
types. Since the ocular lens seems at least partially dependent upon biosynthesis to supply
its required cholesterol, cholesterolgenesis could have a special role in control of cell
proliferation and DNA synthesis in the lens. We thus examined the effects of inhibiting sterol
synthesis with mevinolin upon cell proliferation, upon accumulation of DNA, sterol and
protein mass and upon DNA synthesis by bovine lens epithelial cells cultured in lipoprotein …