Dendritic cells in experimental allergic encephalomyelitis and multiple sclerosis

H Link, YM Huang, BG Xiao - Journal of Neuroimmunology, 1999 - Elsevier
The mechanisms by which autoimmune diseases are triggered and by which the activation
of autoreactive T cells is initiated and maintained are not yet fully understood. As the most
potent antigen presenting cells (APC), and also being responsible for antigen transport as
well as primary sensitisation of T cells, dendritic cells (DC) are capable of breaking the state
of self-ignorance and inducing aggressive autoreactive T cells. In the development of
autoimmune diseases, different types of DC exhibit distinct properties for inducing Th1/Th2 …