Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities
G Lametschwandtner, T Biedermann… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: The transcription factor T-bet mediates IFN-γ production by TH1 cells and
suppresses TH2 cytokine production when ectopically expressed in polarized murine TH2
cells. Thus T-bet–mediated inhibition of TH2 cytokine production might be beneficial for the
treatment of allergic diseases like asthma or atopic dermatitis. OBJECTIVE: We sought to
investigate the effects of ectopic T-bet expression in highly polarized human TH2 cells
obtained from skin biopsy specimens of patients with atopic dermatitis. METHODS: The …
suppresses TH2 cytokine production when ectopically expressed in polarized murine TH2
cells. Thus T-bet–mediated inhibition of TH2 cytokine production might be beneficial for the
treatment of allergic diseases like asthma or atopic dermatitis. OBJECTIVE: We sought to
investigate the effects of ectopic T-bet expression in highly polarized human TH2 cells
obtained from skin biopsy specimens of patients with atopic dermatitis. METHODS: The …