[HTML][HTML] A novel osteoblast-derived C-type lectin that inhibits osteoclast formation
H Zhou, V Kartsogiannis, YS Hu, J Elliott… - Journal of Biological …, 2001 - ASBMB
We have cloned and expressed murineosteoclast inhibitorylectin (mOCIL), a 207-amino acid
type II transmembrane C-type lectin. In osteoclast formation assays of primary murine
calvarial osteoblasts with bone marrow cells, antisense oligonucleotides for mOCIL
increased tartrate-resistant acid phosphatase-positive mononucleate cell formation by 3–5-
fold, whereas control oligonucleotides had no effect. The extracellular domain of mOCIL,
expressed as a recombinant protein inEscherichia coli, dose-dependently inhibited …
type II transmembrane C-type lectin. In osteoclast formation assays of primary murine
calvarial osteoblasts with bone marrow cells, antisense oligonucleotides for mOCIL
increased tartrate-resistant acid phosphatase-positive mononucleate cell formation by 3–5-
fold, whereas control oligonucleotides had no effect. The extracellular domain of mOCIL,
expressed as a recombinant protein inEscherichia coli, dose-dependently inhibited …