[HTML][HTML] MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-κB activation
T cell receptor (TCR) induces a series of signaling cascades and leads to activation of
multiple transcription factors, including NF-κB. Although the mechanism of TCR-induced NF-
κB activation is not fully understood, recent studies indicate that Bcl10 and CARMA1, two
adaptor/scaffold proteins, play essential roles in mediating TCR-induced NF-κB activation.
MALT1/paracaspase is a caspase-like protein that contains an N-terminal death domain, two
Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like …
multiple transcription factors, including NF-κB. Although the mechanism of TCR-induced NF-
κB activation is not fully understood, recent studies indicate that Bcl10 and CARMA1, two
adaptor/scaffold proteins, play essential roles in mediating TCR-induced NF-κB activation.
MALT1/paracaspase is a caspase-like protein that contains an N-terminal death domain, two
Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like …