Risk of cardiovascular events associated with selective COX-2 inhibitors
Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting
inflammation. However, by decreasing vasodilatory and antiaggregatory prostacyclin
production, COX-2 antagonists may lead to increased prothrombotic activity. To define the
cardiovascular effects of COX-2 inhibitors when used for arthritis and musculoskeletal pain
in patients without coronary artery disease, we performed a MEDLINE search to identify all …
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting
inflammation. However, by decreasing vasodilatory and antiaggregatory prostacyclin
production, COX-2 antagonists may lead to increased prothrombotic activity. To define the
cardiovascular effects of COX-2 inhibitors when used for arthritis and musculoskeletal pain
in patients without coronary artery disease, we performed a MEDLINE search to identify all …